Core Infrastructure & Instrumentation Platforms

State-of-the-Art Research Facilities

Explore the advanced instrumentation suites, biophysical platforms, high-throughput flow cytometry, and computational modeling infrastructure powering discovery at MSI Lab.

Apply for Instrument Usage / Service → Explore Instrument Arsenal
Certified Core Infrastructure & Biocontainment

National Center of Excellence for Structural & Viral Immunology

Empowered by the World Bank HEAT Project (HEAT-11009-CU) and MOST grants, providing certified BSL-2 biocontainment, 16+ core analytical platforms, and open research service access.

Platforms
16+
Benchtop Suites
Safety
BSL-2
Certified Suite
Access
Open
Research Service
Apply for Service ↗
Core Experimental Arsenal

State-of-the-Art Research Facilities

Equipped with advanced analytical, biophysical, sequencing, and purification platforms supported by the World Bank HEAT Project, Ministry of Science & Technology (MOST), and Chittagong University.

Beckman Coulter CytoFLEX Flow Cytometer Beckman Coulter
Cellular Immunology

Beckman Coulter CytoFLEX Flow Cytometer

CytoFLEX Research Cytometer

Multiparametric single-cell immunophenotyping, high-sensitivity nanoparticle & extracellular vesicle resolution, and intracellular cytokine dynamics.

Key Techniques:
Single-Cell Phenotyping Extracellular Vesicles (80 nm) Intracellular Cytokine Staining T/B Cell Activation Assays
Specs: WDM optics, up to 3 lasers (488/638/405 nm), 13 channels, 15,000 events/sec, >7 decades linear range.
Manufacturer Portal ↗
Hitachi Chromaster HPLC System Hitachi High-Tech
Analytical Chromatography

Hitachi Chromaster HPLC System

Chromaster Series (5110/5210/5430 DAD)

High-precision separation, quantification of secondary metabolites, bioactive peptide purity checks, and chromatographic validation.

Key Techniques:
Reversed-Phase HPLC Phytochemical Quantification Peptide Purity Profiling Diode Array Detection (DAD)
Specs: Ultra-low pulsation pump (≤0.05% RSD), DAD wavelength 190–900 nm, 0.001–9.999 mL/min flow rate.
Manufacturer Portal ↗
Thermo Scientific Vanquish Core HPLC System Thermo Fisher
Advanced HPLC / UHPLC

Thermo Scientific Vanquish Core HPLC

Vanquish Core HPLC / UHPLC System

High-throughput chromatographic profiling, intact protein/subunit purity verification, peptide mapping, and pharmacokinetics.

Key Techniques:
Recombinant Antigen Purity Peptide Fingerprinting Size-Exclusion Chromatography Charge Variant (IEX)
Specs: Biocompatible fluidics up to 700 bar (10,150 psi), smartTune automated diagnostics, active pre-heating column chamber.
Manufacturer Portal ↗
Haier Biomedical Laboratory Freeze Dryer Haier Biomedical
Lyophilization & Biologics

Haier Biomedical Freeze Dryer

Laboratory Series Lyophilizer

Sublimation drying for thermostable peptide antigens, vaccine candidate formulations, and long-term preservation of sera and enzymes.

Key Techniques:
Antigen Lyophilization Cold-Chain Independence Preservation of Antibodies Vacuum Sublimation
Specs: Condenser down to -80°C / -50°C, microcomputer touch-control, automated defroster and freeze curve memory.
Manufacturer Portal ↗
Haier Biomedical Benchtop High-Speed Refrigerated Centrifuge Haier Biomedical
Refrigerated Centrifugation

Haier Biomedical High-Speed Refrigerated Centrifuge

LX-185T100R / LX-165T2R Series

High-speed refrigerated separation and purification of cellular fractions, macromolecular proteins, blood, body fluids, DNA/RNA, plasmids, bacteria, and viral particles.

Key Techniques:
Cellular Fractionation Plasmid & RNA Pelleting Recombinant Harvest Blood / Serum Clarification
Specs: Max 18,500 rpm / 16,500 rpm, capacity 4 × 100 mL, PID temp control (-20°C to +40°C), Smart Anti-Vibration lock, ≤52 dB(A).
Manufacturer Portal ↗
Analytik Jena qTOWER³ G Real-Time qPCR Thermal Cycler Analytik Jena
Quantitative PCR

Analytik Jena qTOWER³ G qPCR

qTOWER³ G (3G) Real-Time Thermal Cycler

Ultra-fast multiplex quantitative real-time PCR, linear thermal gradient assay optimization, viral load quantification (SARS-CoV-2, DENV 1-4), and host transcriptomics.

Key Techniques:
6-Plex Multiplex qPCR Thermal Gradient Optimization Absolute Viral Copy Number High-Resolution Melting (HRM)
Specs: Patented fiber-optic shuttle system, silver block with gold coating, gradient function over 12 columns, heating rate up to 8°C/s, uniformity ±0.15°C.
Manufacturer Portal ↗
Illumina MiniSeq Sequencing System Illumina
Next-Generation Sequencing

Illumina MiniSeq Sequencing System

MiniSeq Benchtop NGS System

Targeted viral whole-genome sequencing, lineage tracking (DENV variants, SARS-CoV-2 escape mutants), and multiplex gene panels.

Key Techniques:
Viral Whole-Genome Sequencing Variant & Lineage Surveillance Immune Transcriptome RNA-Seq Targeted Amplicon Panels
Specs: Sequencing by Synthesis (SBS), up to 7.5 Gb throughput, 25M single-end / 50M paired-end reads, run time 4–24 hours.
Manufacturer Portal ↗
JASCO FP-8600 Spectrofluorometer JASCO Corporation
Biophysical Spectroscopy

JASCO FP-8600 Spectrofluorometer

FP-8600 High-Sensitivity System

Deep biophysical characterization of protein folding, intrinsic tryptophan fluorescence, macromolecular interactions, and FRET.

Key Techniques:
Intrinsic Tryptophan Quenching Protein Folding & Stability Förster Resonance (FRET) Binding Affinity (Kd) Analysis
Specs: Wavelength range 200–1010 nm (ex/em), S/N ratio >2,500:1 (RMS), rapid scanning up to 60,000 nm/min.
Manufacturer Portal ↗
Tecan Infinite 200 PRO Multimode Microplate Reader Tecan Life Sciences
High-Throughput Bioassays

Tecan Infinite 200 PRO Reader

Infinite 200 PRO (M Plex / F Plex)

Flexible multi-mode microplate assays including high-throughput ELISA, antibody neutralization titers, and enzymatic kinetics.

Key Techniques:
High-Throughput ELISA FRET & Time-Resolved TRF Luminescent Neutralization Enzymatic Inhibition (IC50)
Specs: Quad4 Monochromators & filters, absorbance (200–1000 nm), fluorescence top/bottom, glow/flash luminescence.
Manufacturer Portal ↗
Borosil Scientific OmniTap XS Touch Water Purification System Borosil Scientific
Water Purification

Borosil OmniTap XS Touch Water System

OmniTap XS Touch (Type I & II)

Continuous supply of Type I ultrapure (18.2 MΩ·cm) and Type II pure water essential for NGS, HPLC, cell culture, and enzymatic assays.

Key Techniques:
HPLC & LC-MS Mobile Phases qPCR Reagent Reconstitution Endotoxin-Free Cell Culture RNase/DNase-Free Buffers
Specs: Resistivity 18.2 MΩ·cm at 25°C, TOC < 5 ppb, bacteria < 0.01 CFU/mL, endotoxin < 0.001 EU/mL, smart touch UI.
Manufacturer Portal ↗
Benchmark Scientific Pulse 650 Ultrasonic Homogenizer Benchmark Scientific
Cell Lysis & Homogenization

Benchmark Scientific Pulse 650

Pulse 650™ (DP0650) with Soundproof Enclosure

High-power ultrasonic cavitation for bacterial and mammalian cell disruption, genomic DNA shearing, inclusion body extraction, and nanoparticle emulsification.

Key Techniques:
Ultrasonic Cell Disruption Genomic DNA & Chromatin Shearing Inclusion Body Solubilization Nanoparticle Emulsification
Specs: 650 W power (variable 6.5–650 W), 20–25 kHz frequency, volume 0.1–500 mL, 7" touchscreen, motorized lift, UV-C chamber.
Manufacturer Portal ↗
Haier Biomedical Class II Biological Safety Cabinet Haier Biomedical
Biosafety & Cell Culture

Haier Class II Biological Safety Cabinet

Smart IoT Series (Touchscreen X Series)

Primary biocontainment and sterile barrier for handling infectious arboviruses (Dengue, Chikungunya, SARS-CoV-2), mammalian cell lines, and viral neutralization.

Key Techniques:
Class II Type A2 Containment Aseptic Cell Propagation Live Viral Neutralization Sterile Vaccine Formulation
Specs: Dual ULPA filtration (99.9995% @ 0.12 µm), 7" LCD touchscreen, velocity monitoring, DC ECM blowers, motorized 10° sash.
Manufacturer Portal ↗
Rocker 300 Oil-Free Laboratory Vacuum Pump Rocker Scientific
Filtration & Aspiration

Rocker 300 Oil-Free Vacuum Pump

Rocker 300 (Part No. 167300-22)

Clean, oil-free vacuum generation for sterile media bottle filtration (0.22 µm), microbial testing, tissue culture supernatant aspiration, and sample cleanup.

Key Techniques:
Sterile Bottle Filtration (0.22 µm) Culture Supernatant Aspiration Solid-Phase Extraction (SPE) Microbial Membrane Capture
Specs: Piston oil-free design, Prote™ overflow trap & gauge, max vacuum 105 mbar abs., max flow 23 L/min, quiet 50 dB.
Manufacturer Portal ↗
ASTEC Water Jacketed CO2 Incubator WCI Series ASTEC Bio (Japan)
Cell Incubation & Infection

ASTEC Water Jacketed CO₂ Incubator

WCI-180 / WCI Series

Ultra-stable 37°C temperature homogeneity and precise 5% CO₂ atmosphere for continuous propagation of mammalian cell lines, hybridomas, and live viral infection assays.

Key Techniques:
Cell Propagation & Culture Viral Plaque Assays Water Jacket Stability (±0.1°C) Infrared (IR) CO₂ Control
Specs: Water jacket thermal insulation, dual-beam IR CO₂ sensor (0–20%), stainless interior, copper shelves, auto door heater.
Manufacturer Portal ↗
Euromex Oxion Biological & Epi-Fluorescence Microscope Euromex (Netherlands)
Fluorescence Microscopy

Euromex Oxion Fluorescence Microscope

Oxion Series (Fluorescence Configuration)

Direct immunofluorescence visualization of intracellular viral antigens, fluorophore-conjugated antibody staining, and cytopathic cellular morphology.

Key Techniques:
Epi-Fluorescence Imaging Viral Antigen Localization Brightfield & Phase Contrast Plan Fluarex IOS Optics
Specs: Siedentopf trinocular head 30°, Plan Fluarex IOS infinity optics, 100W mercury / FluoLED epi-illumination, NeoLED light.
Manufacturer Portal ↗
Benchmark Scientific SureAir PCR Workstation Benchmark / Thomas
Aseptic PCR Clean Bench

Benchmark SureAir™ PCR Workstation

SureAir™ Laminar Flow PCR Workstation

Sterile ISO Class 5 vertical laminar clean-air environment for preparing sensitive viral RT-qPCR mastermixes and preventing amplicon contamination.

Key Techniques:
Aerosol-Free qPCR Dispensing UVC (254 nm) Decontamination ISO Class 5 Laminar Flow Pre-PCR Reaction Assembly
Specs: ISO 5 HEPA filter (99.97% @ 0.3 µm), 254 nm UVC lamp with auto-shutoff timer & safety shield, LED light, pipette shelf.
Manufacturer Portal ↗
Safety & Standards

Supporting Infrastructure & Safety Environment

Our instrumentation is operated under strict standard operating procedures (SOPs) complying with bio-risk management guidelines.

Biosafety Level 2

BSL-2 Tissue Culture Suite

Certified Class II biosafety cabinets, CO2 incubators, inverted microscopy, and cryogenic storage for viral neutralization and cell assays.

Cold-Chain Integrity

Cryogenic Specimen Biobank

Ultra-low (-80°C) deep freezers, liquid nitrogen storage, and temperature loggers for long-term clinical serum samples and hybridomas.

Bioprocessing

Recombinant Protein Prep

Automated autoclaves, refrigerated centrifuges, orbital shaking incubators, and sterile filtration assemblies for microbial expression.

In Silico Synergy

Structural Modeling Station

GPU-accelerated computing workstations for molecular dynamics (GROMACS), Rosetta de novo protein engineering, and Cryo-EM models.

Collaborate or Access Our Core Facilities

We welcome applications from motivated students and collaborate with academic groups and clinical research teams seeking access to our specialized platforms.

Apply for Instrument Service & Usage → Collaborative Frameworks Apply for Thesis / Fellowship